Rebecca Mosher

Rebecca Mosher

Professor

Degree(s)

  • 1998 Bachelor of Science with Honors, cum laude, The University of Arizona. Double major in Molecular & Cellular Biology and Biochemistry.
  • 2005 Doctorate of Philosophy, University Program in Genetics and Genomics, Department of Biology, Duke University.
  • 2005 – 2010 Postdoctoral Fellow, The Sainsbury Laboratory, Norwich UK; and the Department of Plant Sciences, Cambridge University, UK.
Research

Eukaryotes contain an array of small RNAs capable of transcriptional and post-transcriptional gene regulation. These ubiquitous molecules are part of many biological processes, including development, response to the environment, and disease. Originally identified in plants, small RNAs are now studied in diverse organisms and are an important tool in human therapeutics. Our laboratory studies the synthesis and action of small RNA molecules with particular emphasis on 1) epigenetic modifications such as DNA methylation during seed development, and 2) evolution of the RNA-directed DNA methylation machinery. We combine traditional genetic and molecular studies with phylogenetic and structural analysis in diverse plant species.

Interests

Eukaryotes contain an array of small RNAs capable of transcriptional and post-transcriptional gene regulation. These ubiquitous molecules are part of many biological processes, including development, response to the environment, and disease. Originally identified in plants, small RNAs are now studied in diverse organisms and are an important tool in human therapeutics. Our laboratory studies the synthesis and action of small RNA molecules with particular emphasis on 1) epigenetic modifications such as DNA methylation during seed development, and 2) evolution of the RNA-directed DNA methylation machinery. We combine traditional genetic and molecular studies with phylogenetic and structural analysis in diverse plant species.

Teaching

PLS449A/549A - Plant Genetics + Genomics