Eukaryotes contain an array of small RNAs capable of transcriptional and post-transcriptional gene regulation. These ubiquitous molecules are part of many biological processes, including development, response to the environment, and disease. Originally identified in plants, small RNAs are now studied in diverse organisms and are an important tool in human therapeutics. Our laboratory studies the synthesis and action of small RNA molecules with particular emphasis on 1) epigenetic modifications such as DNA methylation during seed development, and 2) evolution of the RNA-directed DNA methylation machinery. We combine traditional genetic and molecular studies with phylogenetic and structural analysis in diverse plant species.

Eukaryotes contain an array of small RNAs capable of transcriptional and post-transcriptional gene regulation. These ubiquitous molecules are part of many biological processes, including development, response to the environment, and disease. Originally identified in plants, small RNAs are now studied in diverse organisms and are an important tool in human therapeutics. Our laboratory studies the synthesis and action of small RNA molecules with particular emphasis on 1) epigenetic modifications such as DNA methylation during seed development, and 2) evolution of the RNA-directed DNA methylation machinery. We combine traditional genetic and molecular studies with phylogenetic and structural analysis in diverse plant species.